Frank, "schools of thought" don't replace facts, and one size doesn't fit all.
A lot of people, my wife included, could not handle the recoil of a gun that shoots bullets that "hit like a truck", much less my 9mm Nano. And, hand guns do not deliver "hyper-velocity" rounds. The .357 you mention has a WIDE variation in muzzle velocity and energy, ranging from 294 ft-lbs at 990 ft/sec to 750 ft-lbs at 1650 ft/sec. The .45 ACP varies from 244 ft-lbs at 750 ft/sec to 616 ft-lbs at 1225 ft/sec.
http://www.ballistics101.com/357_magnum.phphttp://www.ballistics101.com/45_acp.phpA .22LR leaves a 3" barrel at 910 ft/sec, which gives it 74 ft-lbs of energy. A solid point round nose will penetrate farther than a hollow point. it is severely disabling and/or lethal. Here are a just a few of countless examples.
http://en.wikipedia.org/wiki/Kauhajoki_school_shootinghttp://en.wikipedia.org/wiki/Cleveland_Elementary_School_shooting_(San_Diego)http://en.wikipedia.org/wiki/Reagan_assassination_attemptNone of these rounds would deliver "knock down" power because hand guns do not knock people down UNLESS they are hit in the brain, brain stem or spine. Even heart shots with any of these rounds can result in the person remaining conscience for 15 seconds to a minute or more, depending on the rate of blood loss. A lot of people appear to be "knocked down" because they think that if they are hit by a bullet from a handgun they have to fall down. (Too many movies? Too many people being "blown away" by hits from a handgun round?) On the other hand, visual proof of the failure of handguns to "knock down" people is shown on many YouTube videos. In an adrenaline rush many people never realize they've been shot, and certainly not knocked down.
The data in the original post shows very clearly that the average number of .22 bullets needed to "knock down" averages less than two.
If adrenaline exciting keeps someone from shooting a .22 accurately it will keep someone from shooting a heavier caliber accurately as well, but someone shooting a .22 pistol won't have to contend with the recoil that would require they re-sight the weapon for a second shot. My wife couldn't get two shots off in under 5 seconds and stay on target. She was able to get 10 shots off in 5 seconds with the HP22A, and fairly accurately as well at 5 yards. And, she can charge the slide on the .22, clear the old mag and insert a new one, things she wasn't able to do with the Nano.
I can guarantee two things: NO ONE is going to look at the muzzle of the HP22A and say, "Oh, that's just a .22. It won't hurt me, just make me mad.", and NO ONE will want to be shot by it.