Never had a .44, but did own a .357 DE ( and stupidly traded it away....sigh ).
Fun gun to shoot, but BIG, BIG, BIG, everything about it was BIG.
Personally for what you are thinking, I would look more towards a revolver ( yea, I know you said you are not a revolver fan, but, sometimes, its the best option )
With factory ammo, my DE was dead reliable, however, with "factory reloads" with lead bullets, it was a singleshot