If you get a Desert Eagle you might also want to get a four wheel cart to haul it around on since it's too big to carry otherwise. Also, any problem with grip could be fixed by putting a stock on it, which wouldn't hurt anything since it's already so big. And then you would need to put a longer barrel on it to make it legal, which would also improve ballistics. And of course once you did all that you'd have a carbine, which is a more realistic form for something so big to take.
I had a Ruger Redhawk .44 that I really enjoyed shooting; one of the most fun guns to shoot I ever had. I remember shooting down at floating ice in a stream and how big things always happened when I pulled he trigger, even at ranges that were long by pistol standards. I finally sold it though and bought my first Glock 9mm with the money because I wanted something more practical. But for the purpose you mention I'd think a .44 revolver would be fine.
I'd like to add my vote to those for the 10mm Glock. I have one, and it's an excellent pistol if you want a combination of stopping power and firepower in a pistol that's not too big to be easy to carry. If I remember right the size, weight, and capacity is very similar to the Beretta 92F, the difference being that the Glock 10mm is hugely more powerful.